Use of sphingosine as inhibitor of protein kinase C.
作者： Yusuf A. Hannun , Alfred H. Merrill , Robert M. Bell
DOI: 10.1016/0076-6879(91)01028-Z
关键词:
摘要: Publisher Summary This chapter discusses the use of sphingosine as inhibitor protein kinase C. Protein C functions an important regulatory element a nearly ubiquitous signal transduction system in mammalian cells. It plays critical roles cell differentiation, tumor promotion, oncogenesis, and processes, such granule secretion hormone release. exists family closely related isoenzymes with differences tissue distribution intracellular localization. are physiologically regulated by diacylglycerol (DAG), which is generated from membrane phospholipids response to stimulation. activated pharmacologically phorbol esters promoters predominant receptor for esters. Therefore, it has been implicated mediating numerous biological activities attributed
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