Cutaneous granulomatous response to BCG cell walls with reference to cancer immunotherapy.

摘要: A chronic inflammatory response produced by cell walls of Mycobacterium bovis strain BCG associated with microscopic oil droplets (BCG CW-O) was studied reference to the tumor-regressing ability this preparation. When CW-O injected intradermally in footpads guinea pigs, intense inflammation developed at site injection and draining popliteal lymph node. This characterized histologically as granulomatous inflammation. The intensity related dose CW-O. Cell without same type but much less degree. Data are presented that demonstrate immunological nature classify it a cell-mediated immune reaction. Ramifications reaction occurring tumor discussed.