The immunopathological effects of intracolonic injection of Mycobacterium bovis BCG cell wall emulsions in guinea pigs.

作者: G.L. Cockerell , R.W. O'Donnell , M.M. Zgola

DOI: 10.1007/BF00205389

关键词:

摘要: The immunological and pathological responses of guinea pigs to an intramural colonic injection emulsions containing cell wall (CW) extracts Mycobacterium bovis BCG mineral oil were studied from week 1 36 post-inoculation. contained variable concentrations CW attached (lipid-phase), or separate (aqueous-phase), the oil. Delayed cutaneous hypersensitivity PPD was present throughout course study in a percentage inoculated with either type emulsion. PPD-induced blast transformation peripheral blood lymphocytes, which received lipid-phase emulsion, also detectable study, maximal response seen 2 weeks intracolonic inoculations well tolerated, exception most concentrated emulsion (3 mg/ml 5% oil), after one eight died due impaction rupture at site inoculation. focal granulomatous colitis, tended be more severe as concentration increased. Extracolonic lesions usually limited lymphadenitis lymph nodes draining site; however, occasionally produced inflammatory foci liver lungs. In general, induced by than those aqueous-phase emulsions, but intensity both types peaked 4 It concluded that pig may serve useful model immunotherapy neoplasms, since resulted systemic immunity toward mycobacterial antigens localized accumulation macrophages without untoward complications.

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