Pathophysiology of traumatic injury in the developing brain: an introduction and short update.

摘要: Current understanding about the main peculiarities in pathophysiology of immature brain traumatic injury involves marked developmental discrepancy biomechanical properties, aspects altered features water and electrolyte homeostasis as well maturation dependent differences structural functional responses major transmitter systems. Based on fact that (TBI) is one causes morbidity mortality infants children, currently available epidemiological data are reviewed order to gain insights scope dimension health care engagement derive requirements for reinforced pathogenetic research. To this end, primary secondary TBI mechanisms immature/developing discussed, including conditions resulting a markedly diminished shear resistance tissue. As such, tissue appears be more susceptible mechanical alterations, because similar load induces intense displacement. Furthermore, indications increased incidence swelling after reviewed, focusing interrelationship between age-dependent extracellular space aquaporin-4 expression during maturation. The induced cerebrovascular response some relevant neurotransmission following regard glutamatergic dopaminergic system assessed. Thus, mini-review highlights progress but also an necessity expanded research clinical scale develop solid foundation adequate therapeutic strategies different life-threatening consequences infancy childhood, which mainly have failed up now.