Induced pluripotent stem cells, past and future
作者： Eirini P. Papapetrou
关键词:
摘要: Ten years ago, Shinya Yamanaka and his student Kazutoshi Takahashi did an experiment of exquisite simplicity elegance that changed biomedical research forever ( 1 ). By showing a set transcription factors could reprogram somatic cells to acquire pluripotent stem cell state, they ushered in the era induced (iPSCs). The discovery made it crystal clear identity is much more malleable than previously thought, provided invaluable tool for disease-oriented translational researchers, bridging reductionism with patient-derived relevance. Combined other maturing technologies, most notably genome editing three-dimensional (3D) culture systems, iPSC technology has enabled investigation was hitherto only possible model organisms 2 , 3
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harvard.edu参考文章(11)
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