Factors determining cell killing by chemotherapeutic agents In Vivo—II.
作者： L.M. Van Putten , P. Lelieveld
DOI: 10.1016/0014-2964(71)90089-2
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摘要: The sensitivity of resting spleen colony-forming cells in normal mouse bone marrow and rapidly-proliferating repopulating to a number bis-chloro-aethyl-amines was determined. rapidly-growing were more sensitive each the agents than cells. equal degree sensitization these by an increased rate proliferation points common mechanism for all this type. It is suggested that repair damaged DNA, excision alkylated bases or oligonucleotides before damage becomes irreversible during next DNA synthetic period, most likely explanation uniform difference caused modified cell proliferation. © 1971. Chemicals/CAS: chlorambucil, 305-03-3; chlormethine, 51-75-2, 55-86-7, 82905-71-3; cyclophosphamide, 50-18-0; 9007-49-2; melphalan, 148-82-3; Chlorambucil, Cyclophosphamide, Mechlorethamine, 51-75-2; Melphalan, 148-82-3
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