Interphase cell death as related to the cell cycle of melphalan-treated human myeloma cells.
作者： Sven Skog , Rolf Lewensohn , Jan-Olof Fernberg
DOI: 10.1007/BF02988855
关键词: Cancer research 、 Nitrogen mustard 、 Population 、 Cell cycle 、 Immunology 、 Biology 、 Mitosis 、 Melphalan 、 Interphase 、 Cell growth 、 Programmed cell death
摘要: The effect of melphalan on cell loss, growth and cell-cycle traverse was studied the human myeloma line RPMI 8226. Melphalan treatment resulted in arrest cells late S- G2-phases a population unsynchronized cells. At high concentrations (e.g. 40 μm), loss noticed duringthe first cycle after addition to aforementioned S G2. further analysed enriched for G1-phase. Cell death this occurred between 24 48 hr as were moving over
springer.com
sci-hub.se 参考文章(12)
SE Salmon, Expansion of the growth fraction in multiple myeloma with alkylating agents Blood. ,vol. 45, pp. 119- 129 ,(1975) , 10.1182/BLOOD.V45.1.119.119
L.M. Van Putten, P. Lelieveld, Factors determining cell killing by chemotherapeutic agents In Vivo—II. European Journal of Cancer (1965). ,vol. 7, pp. 11- 16 ,(1971) , 10.1016/0014-2964(71)90089-2
Peter J. Selby, Timothy J. McElwain, Ann C. Nandi, Timothy J. Perren, Raymond L. Powles, Colin R. Tillyer, Richard J. Osborne, Maurice L. Slevin, James S. Malpas, Multiple myeloma treated with high dose intravenous melphalan British Journal of Haematology. ,vol. 66, pp. 55- 62 ,(1987) , 10.1111/J.1365-2141.1987.TB06890.X
Benjamin Drewinko, Barry W. Brown, Ronald Humphrey, Raymond Alexanlan, Effect of chemotherapy on the labelling index of myeloma cells Cancer. ,vol. 34, pp. 526- 531 ,(1974) , 10.1002/1097-0142(197409)34:3<526::AID-CNCR2820340308>3.0.CO;2-R
Andrew G. Bosanquet, Edward D. Gilby, Pharmacokinetics of oral and intravenous melphalan during routine treatment of multiple myeloma. European Journal of Cancer and Clinical Oncology. ,vol. 18, pp. 355- 362 ,(1982) , 10.1016/0277-5379(82)90006-2
Raymond E. Meyn, David Murray, Cell cycle effects of alkylating agents Pharmacology & Therapeutics. ,vol. 24, pp. 147- 163 ,(1984) , 10.1016/0163-7258(84)90032-9
J.J. Roberts, T.P. Brent, A.R. Crathorn, Evidence for the inactivation and repair of the mammalian DNA template after alkylation by mustard gas and half mustard gas European Journal of Cancer (1965). ,vol. 7, pp. 515- 524 ,(1971) , 10.1016/0014-2964(71)90056-9
Raymond E. Meyn, David Murray, Cell Cycle-dependent Cytotoxicity of Alkylating Agents: Determination of Nitrogen Mustard-induced DNA Cross-Links and Their Repair in Chinese Hamster Ovary Cells Synchronized by Centrifugal Elutriation Cancer Research. ,vol. 46, pp. 2324- 2329 ,(1986)
Judith M. Clarkson, David L. Mitchell, The Importance of DNA Damage and Repair in the Cell Cycle Sensitivity of CHO Cells to Nitrogen Mustard Radiation Research. ,vol. 88, pp. 587- 596 ,(1981) , 10.2307/3575647
RAYMOND ALEXANIAN, DANIEL E. BERGSAGEL, PHILIP J. MIGLIORE, WILLIAM K. VAUGHN, CLIFTON D. HOWE, Melphalan therapy for plasma cell myeloma. Blood. ,vol. 31, pp. 1- 10 ,(1968) , 10.1182/BLOOD.V31.1.1.1