Effect of hydralazine on perfusion and metabolism in the leg during upright bicycle exercise in patients with heart failure.

摘要: The aerobic exercise capacity of patients with chronic heart failure is frequently impaired because inadequate O2 transport to working skeletal muscle. To determine whether hydralazine improves muscle, we examined the effect intravenous on blood flow (measured by thermodilution) and metabolism in leg during maximal upright bicycle 10 failure. Hydralazine increased cardiac output (5.6 +/- 0.7 6.7 0.6 l/min; p less than .01) decreased systemic extraction (79 3% 65 2%; but did not alter uptake (787 105 vs 779 82 ml/min). Leg at from 1.6 0.2 2.1 0.4 l/min (p .03); proportion delivered remained unchanged (59 57 9%). This increase was associated a decrease (84 2% 79 no change peak femoral venous lactate (59.1 7.4 54.1 5.3 mg/dl), suggesting that there functional or anatomic shunting augmented limb rather delivery metabolizing These data suggest augments exercising this does oxygen availability within