Quantification of water diffusion and relaxation times of human U87 tumors in a mouse model

摘要: Assessing the potential of anti-cancer agents can be greatly facilitated by applying MRI methods to investigations with animal models. Quantitative diffusion imaging, T1, and T2 measurements may offer valuable information for understanding properties tumor evaluating new therapeutic approaches. The human U87 high-grade glial is widely used cancer in orthotopic murine physiological features this model at cellular sub-cellular level have not, however, been well characterized MRI. In study, we measured diffusion, T1 characteristics water 8.5 T an vivo analyzed their detailed changes transition from core through periphery, out surrounding tissue using custom developed radial profile analysis software. For bearing mice (n = 10), mean average apparent coefficient (ADC) was 1.03 ± 0.02 ( × 10−3 mm2/s), while contralateral normal brain it 0.73 ± 0.03 ( × 10−3 mm2/s). 2.03 ± 0.08 s 1.64 ± 0.06 s. 0.062 ± 0.002 s 0.048 ± 0.001 s. ADC, compared were significantly different (p < 0.005). Copyright © 2004 John Wiley & Sons, Ltd.