Temporal and dose dependence of T2 and ADC at 9.4 T in a mouse model following single fraction radiation therapy.

摘要: The purpose of this study is to use magnetic resonance imaging monitor the response human glioma tumor xenografts single fraction radiation therapy. Mice were divided into four treatment groups ( n = 6 per group) that received 50, 200, 400, or 800 cGy 200 kVp x rays. A fifth group ) no radiationdose and served as control. Quantitative maps treatedtumortissue produced water apparent diffusion coefficient (ADC) transverse relaxation time (T2). imaged before at multiple points after treatment. There was a statistically significant difference in growth relative control for all groups. Only highest dose showed T2 values significantly different measured In group, there an 8.3% increase controls 2 days treatment, but when 14 mean had dropped 10.1% below initial value. ADC differences from points. dependence observed. fractional increases higher than those observed T2. sensitive radiation-induced changes lower did not have change. At doses, elevation preceded deviations These observations support potential application marker