Assessment of Rodent Glioma Models Using Magnetic Resonance Imaging Techniques

摘要: There is a strong need to obtain precise surrogate biomarkers improve the accuracy of diagnosis for gliomas, and effectively evaluate therapeutic response. Often pre-clinical models disease are used develop diagnostic procedures assess effectiveness potential therapy. For there variety rodent that have been investigated by numerous investigators over past few decades, ranging from intracranial glioma cell implantation models, human xenografts, orthotopic stem cells, multipotent glioblastoma stem-like neurosphere lines, transgenic mouse viral-induced progenitor or derived models. Tumor grades in these vary low high grade tumors, with many high-grade sharing some characteristics IV multiforme (GBM). Many characteristic features gliomas can be assessed diagnostically vivo imaging techniques such as magnetic resonance (MRI). MRI has capability obtaining morphological/anatomical, functional, biophysical, molecular metabolic information at various pathological stages development. often associated aggressive include an invasive growth pattern, angiogenesis, necrosis, hypoxia, edema, alterations major pathways. Morphological features, tumor size position, infiltrative growth, hemorrhaging, necrotic lesions, mass effect, heterogeneity, cyst formation, followed using standard contrast-enhanced T1-weighted MR non-contrast T2-weighted imaging. Although conventional provides us indication about nature lesion tumor, it limited sensitivity specificity determining histological type grade, delineating margins differentiating well evaluating effects side-effects. Incorporating advanced techniques, angiography (MRA), perfusion-weighted (PWI), diffusion-weighted (DWI), spectroscopy (MRS), (mMRI), may help overcome those limitations. Angiogenesis blood vessels angiography, whereas monitor angiogenesis capillary tumors. Biophysical parameters water diffusion, measured imaging, also provided