Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas.

摘要: Human low-grade gliomas represent a population of brain tumors that remain therapeutic challenge. Preclinical evaluation agents, to test their preventive or efficacy in these tumors, requires the use animal nobreak models. Spontaneous develop models chemically induced carcinogenesis, such as transplacental N-ethyl-N-nitrosourea (ENU) rat model. However, without ability detect initial tumor formation, multiplicity measure growth rates, it is difficult compounds for interventional preventional capabilities. In this study Fisher-334 rats, treated transplacentally with ENU, underwent magnetic resonance imaging (MRI) examination order evaluate approach detection formation and growth. ENU-induced intracranial cerebral were first observable T2-weighted images beginning at 4 months age grew mean doubling time 0.487 ± 0.112 months. These found histologically be predominately mixed gliomas. Two interventions evaluated using MRI, vitamin A (all-trans retinol palmitate, RP), chemopreventative agent anti-angiogenic drug SU-5416. RP was significantly delay observation by one month (P = 0.05). No differences rates observed between control RP-treated groups. MRI studies rats SU-5416 resulted reduction compared matched controls. results show can used provide novel information relating agents against