Spotty Calcium on Cervicocerebral Computed Tomography Angiography Associates With Increased Risk of Ischemic Stroke

摘要: Background and Purpose- Cervicocerebral vascular calcification on computed tomography angiography is a known sign of advanced atherosclerosis. However, the clinical significance pattern remains unclear. In this study, we aimed to investigate potential association between spotty calcium acute ischemic stroke. Methods- This study included patients with first-time nonlacunar stroke (N=50) confirmed by brain magnetic resonance imaging or nonenhanced head tomography, as well control subjects asymptomatic carotid atherosclerosis ultrasonography. Subjects in both groups underwent contrast-enhanced cervicocerebral within week after initial examination. Spotty was evaluated at 11 arterial segments commonly affected along vertebrobasilar circulation. Statistical analysis performed comparing frequency spatial 2 groups. Results- Stroke group markedly more prevalent than that Control (total SC count: 8.74±4.96 versus 1.84±1.82, P<0.001). The odds ratio (95% CI) for 2.49 (1.55-4.00) bilateral bifurcation, 1.52 (1.13-2.04) siphon, 1.98 (1.45-2.69) all locations. A total number 3 calcifications were determined optimal cutoff threshold increased risk showed significantly greater area under receiver operating characteristics curve volume irrespective size (0.88 0.77). Within group, ipsilateral lateral side contralateral (5.18±3.05 3.56±2.67, Conclusions- Nonlacunar ischemia associated incidence distinct compared subclinical atherosclerosis, suggesting role improving stratification