Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour-bearing rats
作者： Maite Figueras , Sı́lvia Busquets , Neus Carbó , Esther Barreiro , Vanessa Almendro
DOI: 10.1016/J.FEBSLET.2004.05.066
关键词:
摘要: Administration of interleukin-15 (IL-15) to rats bearing the Yoshida AH-130 ascites hepatoma (a tumour that induces an important cachectic response) resulted in a significant reduction muscle wasting, both measured as weight and protein content different types skeletal muscle. In addition, administration cytokine completely reversed increased DNA fragmentation observed tumour-bearing animals. Concerning mechanism(s) involved anti-apoptotic effects IL-15 on muscle, considerable decrease R1 (43%) R2 (64%) TNF-α receptors (TNFRs), therefore it may be suggested decreases apoptosis by affecting signalling. Formation NO could signalling event associated with activation rats; indeed, decreased inducible nitric oxide synthase levels 73%, suggesting formation during growth are related. conclusion, seems able reduce/suppress loss related wasting cancer cachexia experimental
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