Integration status of virus DNA and p53 codon 72 polymorphism in human papillomavirus type 16 positive cervical cancers.

摘要: Background. The aim of this study was to determine the physical state HPV 16 DNA and reveal any association between virus pathologic or prognostic factors in HPV16 positive cervical cancers. other estimate role p53 codon 72 polymorphism disease progression. Materials Methods. presence analysed by Southern blot hybridisation E1-E2 specific PCRs primary tumours pelvic lymph nodes 85 carcinoma patients. Results Integrated found 32 out 41 (78 %) 2 22 (95 carrying DNA. No significant integration course disease. There a trend towards an associahon recurrence arginine homozygous genotype (OR = 3.41, p 0.23). Conclusion. does not seem play major as indicator Hungarian cancer patients, while may have impact on clinical outcome