TIMP1 tissue inhibitor of metalloproteinase-1, erythroid potentiating activity, EPA

摘要: Tissue inhibitor of metalloproteinase 1 (TIMP1) is a secreted 184 amino acid glycoprotein having molecular mass 28,500 Da. It contains two sites for N-linked glycosylation, with variable sialic substitution, which not necessary inhibitory function. The molecule comprises six loops held in place by disulphide bonds. TIMP1 can be purified from the conditioned medium fibroblasts stimulated phorbol myristate acetate or cytokines such as interleukin-1. has been isolated culture fetal lung and other fibroblasts. TIMPs regulate activation proteolytic activity matrix metalloproteinases (MMPs) therefore play fundamental role controlling extracellular degradation. have roles important biological processes development, erythroid-potentiation, cell-growth regulation, cancer cell invasion metastasis, degenerative diseases arthritis.