Steroid hormones, receptors, and antagonists.

摘要: In the thirty-odd years since first demonstration of estrogen-binding components in reproductive tissues, much has been learned about molecular details steroid hormone action. Facts still to be elucidated include precise mechanism by which interaction with disrupts native receptor complex generate an active transcription factor, just how this activated enhances expression target genes, and role phosphorylation these events. The concept receptor-medicated action provided useful methods for predicting risk metastatic recurrence breast cancers response disseminated disease endocrine therapy. Application immunochemical techniques assay elucidation mutant receptors resistance promise increase utility diagnostic procedures. A better understanding antagonism should helpful search new more effective agents control cancers.