Sex Hormone-binding Globulin Influences Gene Expression of LNCaP and MCF-7 Cells in Response to Androgen and Estrogen Treatment
作者： Scott M. Kahn , Yu-Hua Li , Daniel J. Hryb , Atif M. Nakhla , Nicholas A. Romas
DOI: 10.1007/978-0-387-69080-3_57
关键词: Receptor 、 Signal transduction 、 LNCaP 、 Androgen receptor 、 Sex hormone-binding globulin 、 Internal medicine 、 Endocrinology 、 Prostate 、 Androgen 、 Estrogen 、 Chemistry
摘要: Sex hormone-binding globulin (SHBG), a plasma protein that binds androgens and estrogens, also participates in the initial steps of membrane-based steroid signaling pathway human prostate breast. We have recently shown SHBG is expressed at mRNA levels In this study, we addressed whether locally SHBG: (1) Functions to regulate activation (2) influences androgen (AR) estrogen (ER) receptors. Using microarray analysis, identified specific genes are influenced by expression LNCaP MCF-7 cells manner consistent with each these properties. These findings suggest can play functional role responsiveness breast through multiple pathways perturbations local could contribute cancer.
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