The control of progesterone receptor expression in MCF-7 breast cancer cells: effects of estradiol and sex hormone-binding globulin (SHBG)

摘要: Estradiol controls the gene transcription and expression of many proteins in breast cancer cells, like progesterone receptor, PR, that is up-regulated by hormone. Moreover, estradiol one crucial factors inducing proliferation cells. Sex Hormone-Binding Globulin (SHBG), plasma carrier for both androgens, inhibits estradiol-induced growth MCF-7 cells (estrogen-dependent cells), through its membrane receptor (SHBG-R), cAMP PKA. The anti-estrogenic effect SHBG, which has been described only as far cell concerned, could also play a meaningful role control other In present study, SHBG on PR (both mRNA protein) function (receptor binding capacity) was examined. inhibited up-regulation well protein level function. showed to be specific mediated intermediacy PKA control, together with observation it effective condition activated, supports hypothesis receptor-mediated. ability inhibit action way estrogen-dependent has, therefore, taken into account development future therapeutic strategies.