Pharmacological approaches to improve endothelial repair mechanisms

摘要: Endothelial injury is thought to play a pivotal role in the development and progression of vascular diseases, such as atherosclerosis, hypertension or restenosis, well their complications, including myocardial infarction stroke. Accumulating evidence suggests that bone marrow-derived endothelial progenitor cells (EPCs) promote repair contribute ischemia-induced neovascularization. Coronary artery disease its risk factors, diabetes, hypercholesterolemia, smoking, are associated with reduced number impaired functional activity circulating EPCs. Moreover, initial data suggest EPC levels dysfunction an increased cardiovascular events, compatible concept EPC-mediated promotes disease. In this review we summarize recent on effects pharmacological agents mobilization particular, ...