Highly expressed lncRNA FAL1 promotes the progression of gastric cancer by inhibiting PTEN.

摘要: Objective The aim of this study was to investigate the function FAL1 in gastric cancer (GC) development and examine its underlying mechanism. Our might provide a theoretical basis for developing novel diagnostic markers GC. Patients methods expression GC tissues adjacent detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). serum level patients with different pathological grades further detected. effects on cell proliferation cycle were counting kit-8 (CCK-8) assay flow cytometry, respectively. Meanwhile, Western blot used detect protein PTEN after overexpression or knockdown cells. In addition, rescue experiments conducted verify regulatory effect PTEN. Results QRT-PCR results showed that remarkably higher than tissues. correlated patients. promoted BGC-823 MGC-803 analysis demonstrated could inhibit indicated partially reverse Conclusions can promote via inhibiting