Genetics of New-Onset Diabetes after Transplantation

摘要: New-onset diabetes after transplantation is a common complication that reduces recipient survival. Research in renal transplant recipients has suggested pancreatic β-cell dysfunction, as opposed to insulin resistance, may be the key pathologic process. In this study, clinical and genetic factors associated with new-onset were identified white population. A joint analysis approach, an initial genome-wide association study subset of cases followed by de novo genotyping complete case cohort, was implemented identify single-nucleotide polymorphisms (SNPs) development transplantation. Clinical variables included older age, female sex, percentage weight gain within 12 months The 26 SNPs transplantation; validated for eight (rs10484821, rs7533125, rs2861484, rs11580170, rs2020902, rs1836882, rs198372, rs4394754) genotyping. These associations remained significant multivariate adjustment variables. Seven these are genes implicated apoptosis. results corroborate recent evidence implicating dysfunction pathophysiology support pursuit therapeutic strategies protect β cells post-transplant period.