Induction and maintenance of tolerance to composite tissue allografts

作者: Maria Z. Siemionow

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摘要: The present invention provides a clinically-applicable approach for inducing long-term, donor-specific tolerance to donor antigens, especially in recipients of CTA and/or solid organ transplants, without the requirement patient preconditioning, need chronic immunosuppressive regimens, and occurrence GVHD. In particular, method is provided semi-allogeneic or fully-allogeneic transplant recipient by administering therapeutically effective amount an agent that depletes T cells anti-αβ cell receptor antibodies, implanting allograft into recipient.

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