Opposing effects of glucocorticoids on interferon-gamma-induced murine macrophage Fc receptor and Ia antigen expression.

摘要: Two macrophage markers associated with differentiation are the Fc receptor (FcR) and Ia antigen. Expression of these is increased IFN-gamma treatment, although some evidence suggests that induction pathway for antigen expression may be dissociable. In this study, effect glucocorticoids on basal IFN-induced levels Fc-mediated phagocytosis was investigated. Macrophages incubated 2 days alone showed no change in phagocytosis. However, incubation plus resulted binding to a much greater extent than treatment alone. This enhancement specific IFN-gamma, because IFN-beta-induced increase not affected by glucocorticoids. contrast capacity, both IFN-gamma-induced were inhibited The glucocorticoid two observed other steroid hormones, nor it altered inhibitors arachidonic acid pathway. findings study provide additional occurs different mechanisms.