Cartilage restoration in haemophilia: advanced therapies

摘要: Summary. Current treatment of joint cartilage lesionsis based either on conventional techniques (bonemarrow stimulation, osteochondral autograft or allo-graft transplantation) newly developed tech-niques (chondrocyte implantation and those oncell therapy that use bioreactors, growth factors,mesenchymal stem cells [MSCs] genetically mod-ified cells). The aim this article is to review thetherapeutic strategies above mentioned deter-mine whether the chondral damage seen in haemo-philia could benefit from any them. differentconventional have shown similar resultswhereas autologous chondrocyte implantation, whichis common at present time, has not beenshown produce conclusive results lead tothe formation hyaline cartilage. MSCs hold promisefor repair given their differenti-ation capacity therapeutic effect. ofbioreactors factors, which stimulate carti-lage formation, may optimize such thecontext reimplantation chondrocytes, differenti-ated progenitor cells. ofcell restoration function through therepair damaged tissue stimulation growthfactor synthesis. Implantation chondro-cytes was up now able address onlyhighly localized lesions. Adequate control ofthe differentiation process as well growthfactors appropriate bioreactors transformcell-based therapies into a more efficient longerterm even for patients with haemophilia.Nevertheless, raising false expectations thesepatients should be avoided. There are number ofapproaches haemophilicarthropathy, currently being explored forother related degenerative disorders. If it can beproven effective disorders whichclinical trials ongoing costs limited, itmight an useful palliative approach haemophilicarthropathy. However, we still long way gofor haemophilic arthropathy.Keywords: advanced therapies, cartilage, haemophilia,restoration