Pancreatic stellate cells – Multi-functional cells in the pancreas

摘要: There is accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal role in fibrosis chronic pancreatitis and cancer. In addition, we have seen great progress our understanding of the cell biology PSCs interactions between other types pancreas. response to injury or inflammation, quiescent are myofibroblast-like cells. Recent studies shown activation intracellular signaling pathways such as mitogen-activated protein kinases plays PSCs. microRNAs might also role, because microRNA expression profiles dramatically altered process activation. addition producing extracellular matrix components type I collagen, wide variety functions related local immunity, angiogenesis, exocrine endocrine From this point view, cells, cancer attracted increasing attention researchers. regulate pancreas through cholecystokinin-induced release acetylcholine. induce apoptosis decrease insulin β-cells, suggesting novel mechanism diabetes diseased promote progression by multiple mechanisms. epithelial-mesenchymal transition enhance stem-cell like features conclusion, should now be recognized not only profibrogenic but multi-functional