Dietary Zinc Supplementation to the Donor Improves Insulin Secretion After Islet Transplantation in Chemically Induced Diabetic Rats
作者： Takehiro Mishima , Tamotsu Kuroki , Yoshitsugu Tajima , Tomohiko Adachi , Masataka Hirabaru
DOI: 10.1097/MPA.0000000000000093
关键词:
摘要: OBJECTIVES Zinc (Zn) is related to insulin synthesis, storage, and secretion. This study demonstrates the effects of Zn supplementation in donor rats on outcomes islet transplantation. METHODS Donor received 3 different regimens dietary for 2 weeks before undergoing pancreas donation: a standard diet containing at 50 ppm (control), 1 (low-Zn group) or 1000 (high-Zn group), respectively. Diabetic recipient underwent transplantation, blood glucose levels secretion were monitored 7 days after RESULTS The serum pancreatic time donation significantly lower low-Zn group (48.8 ± 25.5 µg/dL 11.3 1.9 µg/g) higher high-Zn (147.3 17.6 18.7 2.2 when compared with those observed controls (118.7 7.9 14.6 2.0 (P < 0.05). became re-elevated transplantation receiving grafts from groups. In contrast, that islets groups, these maintained within reference range 0.01). CONCLUSIONS These data indicate Zn-rich improves function chemically induced diabetic rats.
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