Pioglitazone treatment increases spontaneous growth hormone (GH) secretion and stimulated GH levels in polycystic ovary syndrome.
作者： Dorte Glintborg , René Klinkby Støving , Claus Hagen , Anne Pernille Hermann , Jan Frystyk
DOI: 10.1210/JC.2005-0615
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摘要: Background: Low GH levels, probably due to insulin resistance and increased abdominal fat mass, are well described in polycystic ovary syndrome (PCOS). acts as an important ovarian cogonadotropin, disturbances may be additional pathogenic factor PCOS. Decreased mass improved sensitivity during pioglitazone treatment affect secretion. Objective: The objective of the study was investigate effect on levels Design: Thirty insulin-resistant PCOS patients were randomized either 16 wk (30 mg/d) or placebo treatment. Before after intervention, fasting insulin, GH, total IGF-I, free IGF binding protein-1, IGF-II, fatty acids, testosterone, SHBG measured. Patients underwent whole-body dual x-ray absorptiometry scans, pyridostigmine-GHRH tests, 24-h 20-min integrated blood sampling for measurement GH. Results: Peak area under curve test...
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