Soluble ST2 and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction.

摘要: BACKGROUND Identifying patients at risk of poor diuretic response in acute heart failure (AHF) is critical to make prompt adjustments therapy. The objective this study was investigate whether the circulating levels soluble ST2 predict cumulative efficiency (DE) 24 and 72 hours with AHF concomitant renal dysfunction. METHODS AND RESULTS This a post hoc analysis IMPROVE-HF trial, which we enrolled 160 dysfunction (estimated glomerular filtrate rate <60 mL/min/1.73 m2). DE calculated as net fluid output produced per 40 mg furosemide equivalents. association between sST2 evaluated by using multivariate linear regression analysis. median hour 747 mL (interquartile range 490-1167 mL) 1844 1142-2625 mL), respectively. mean estimated were ng/mL 47-117 ng/mL), 34.0 ± 8.5 m2, In multivariable setting, higher significant nonlinearly related lower both (P = .002 P = .019, respectively). CONCLUSIONS presentation, independently negatively associated response, hours.