Pathological Correlates of Late Drug-Eluting Stent Thrombosis Strut Coverage as a Marker of Endothelialization

摘要: Background— Late stent thrombosis (LST) after Cypher and Taxus drug-eluting placement has emerged as a major concern. Although the clinical predictors of LST have been reported, specific morphological histological correlates remain unknown. Methods Results— From registry totaling 81 human autopsies stents, 46 (62 lesions) had implanted >30 days. We identified 28 lesions with thrombus compared those 34 similar duration without using computer-guided morphometric analyses. was defined an acute within coronary artery in place Multiple logistic generalized estimating equations modeling demonstrated that endothelialization best predictor thrombosis. The parameter correlated ratio uncovered to total struts per section. A univariable model occurrence i...