Early Effects of Whole-Body 56Fe Irradiation on Hippocampal Function in C57BL/6J Mice
作者： Gwendolen E. Haley , Lauren Yeiser , Reid H. J. Olsen , Matthew J. Davis , Lance A. Johnson
DOI: 10.1667/RR2946.1
关键词:
摘要: Relatively little is known about early irradiation effects on hippocampal function in wild-type mice. In this study, the of (56)Fe were assessed starting 2 weeks after whole-body irradiation. Compared to sham irradiation, radiation impaired novel object recognition female and male C57BL/6J There no contextual fear conditioning or spatial memory retention water maze. It possible that oxidative damage might contribute radiation-induced cognitive changes. Therefore, cortical levels 3-nitrotyrosine (3NT) lipid peroxidation, measures assessed. these damage. As can increase reactive oxygen species (ROS) levels, which may impairments recognition, antioxidant alpha-lipoic acid (ALA) cognition following also ALA did not prevent sham-irradiated irradiated mice probe trial first day hidden platform training Thus, test particularly sensitive detect through a mechanism unlikely involving ROS
allenpress.com
rrjournal.org
elsevier.com
harvard.edu参考文章(25)
D. Allan Butterfield, Earl R. Stadtman, Chapter 7 Protein Oxidation Processes in Aging Brain The Aging Brain. ,vol. 2, pp. 161- 191 ,(1997) , 10.1016/S1566-3124(08)60057-7
K MANDA, M UENO, K ANZAI, Memory impairment, oxidative damage and apoptosis induced by space radiation: Ameliorative potential of α-lipoic acid Behavioural Brain Research. ,vol. 187, pp. 387- 395 ,(2008) , 10.1016/J.BBR.2007.09.033
Heide Hörtnagl, Linda Hansen, Gisela Kindel, Barbara Schneider, Ahmed El Tamert, Israel Hanin, Sex differences and estrous cycle-variations in the AF64A-induced cholinergic deficit in the rat hippocampus. Brain Research Bulletin. ,vol. 31, pp. 129- 134 ,(1993) , 10.1016/0361-9230(93)90019-8
Bernard M. Rabin, Kirsty Carrihill-Knoll, Marie Hinchman, Barbara Shukitt-Hale, James A. Joseph, Brian C. Foster, Effects of heavy particle irradiation and diet on object recognition memory in rats Advances in Space Research. ,vol. 43, pp. 1193- 1199 ,(2009) , 10.1016/J.ASR.2009.01.015
Gwendolen E. Haley, Chris Kroenke, Daniel Schwartz, Steven G. Kohama, Henryk F. Urbanski, Jacob Raber, Hippocampal M1 receptor function associated with spatial learning and memory in aged female rhesus macaques AGE. ,vol. 33, pp. 309- 320 ,(2011) , 10.1007/S11357-010-9184-2
Jacob Raber, Laura Villasana, Jenna Rosenberg, Yani Zou, Ting Ting Huang, John R. Fike, Irradiation enhances hippocampus‐dependent cognition in mice deficient in extracellular superoxide dismutase Hippocampus. ,vol. 21, pp. 72- 80 ,(2011) , 10.1002/HIPO.20724
Laura E. Villasana, Theodore S. Benice, Jacob Raber, Long-term effects of 56Fe irradiation on spatial memory of mice: Role of sex and apolipoprotein e isoform International Journal of Radiation Oncology Biology Physics. ,vol. 80, pp. 567- 573 ,(2011) , 10.1016/J.IJROBP.2010.12.034
Laura Villasana, Jenna Rosenberg, Jacob Raber, Sex-dependent effects of 56Fe irradiation on contextual fear conditioning in C57BL/6J mice. Hippocampus. ,vol. 20, pp. 19- 23 ,(2009) , 10.1002/HIPO.20659
BERNARD M. RABIN, LYNN L. BUHLER, JAMES A. JOSEPH, BARBARA SHUKITT-HALE, DANIEL G. JENKINS, Effects of exposure to 56Fe particles or protons on fixed-ratio operant responding in rats. Journal of Radiation Research. ,vol. 43, ,(2002) , 10.1269/JRR.43.S225
Lester Packer, Hans J. Tritschler, Klaus Wessel, Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid Free Radical Biology and Medicine. ,vol. 22, pp. 359- 378 ,(1997) , 10.1016/S0891-5849(96)00269-9