Post-training gamma irradiation-enhanced contextual fear memory associated with reduced neuronal activation of the infralimbic cortex.

摘要: The brain might be exposed to irradiation under a variety of situations, including clinical treatments, nuclear accidents, dirty bomb scenarios, and military space missions. Correctly recalling tasks learned prior is important but little known about post-learning effects irradiation. It not clear whether exposure X-ray during memory consolidation, few hours following training, associated with altered contextual fear conditioning 24h after which region(s) involved in these effects. Brain immunoreactivity patterns the immediately early gene c-Fos, marker cellular activity was used determine areas post-training retention tasks. In this study, we show that gamma (1 Gy) enhanced later reduced activation infralimbic cortex. Reduced GABA-ergic neurotransmission parvalbumin-positive cells cortex play role radiation-enhanced memory.