The Role of Cell Adhesion, Cell Junctions, and Extracellular Matrix in Development and Carcinogenesis
作者： Anderson K. Santos , Fernanda M. P. Tonelli , Daniel A. F. Silva , Kátia N. Gomes , Luiz O. Ladeira
DOI: 10.1007/978-94-007-6211-4_2
关键词:
摘要: Cells express different cell adhesion molecules (CAMs) which guarantee anchorage, polarity, and support for cells. However, CAMs do not only act mechanically as contact sites between the extracellular matrix or neighboring cells, but also trigger signaling pathways, including survival proliferation. In this chapter, we discuss molecular basis of junctions, effects cell–extracellular cell–cell on normal survival, mechanisms invasion metastasis formation during cancer development. The study pathological processes specifically related to role junctions may provide novel targets therapy.
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