Fermented Ginseng Extract, BST204, Suppresses Tumorigenesis and Migration of Embryonic Carcinoma through Inhibition of Cancer Stem Cell Properties.

摘要: The pharmacological effects of BST204-a fermented ginseng extract-on several types cancers have been reported. However, the products or single ginsenosides against cancer stem cells are still poorly understood. In this study, we identified anti-tumorigenic and anti-invasive activities BST204 through suppression cell marker, CD133. treatment embryonic carcinoma with induced expression tumor suppressor protein, p53, which decreased cycle regulatory proteins downregulated CD133 stemness transcription factors. These changes resulted in both inhibition proliferation tumorigenesis. knockdown suggests that it has a role tumorigenesis, but not arrest. Treatment reduced mesenchymal N-cadherin, increased epithelial E-cadherin, leading to migration invasion. also exhibited an effect, indicating Rg3 Rh2-major components BST204-exhibited limited compared BST204, suggesting possible synergism among ginsenoside compounds.