Race Does Not Impact Outcome for Advanced Ovarian Cancer Patients Treated With Cisplatin/Paclitaxel: An Analysis of Gynecologic Oncology Group Trials

摘要: BACKGROUND: The objectives of this study were to confirm whether racial disparity exists with regard outcome between black women and white ovarian cancer identify factors associated the administration adjuvant treatment that had an impact on survival. METHODS: A retrospective review 97 1392 International Federation Gynecology Obstetrics stage III/IV carcinoma was performed. All patients received paclitaxel combined cisplatin while participating in 1 7 Gynecologic Oncology Group clinical trials. The parameters reviewed included relative dose, time, dose intensity. outcomes compared patients. RESULTS: There no differences (0.90 vs 0.89), time (1.02 0.99), or intensity 0.91) patients. Black less grade 3 4 leukopenia (53% 63%; P 0, age ≥70 years, mucinous histology not completing (P .05 for all). CONCLUSIONS: When they similar treatment, there difference advanced epithelial when as participants may experience severe gastrointestinal toxicity whites treated platinum-based chemotherapy. Cancer 2009. Published 2009 by American Society.