A multi-center population-based case–control study of ovarian cancer in African-American women: the African American Cancer Epidemiology Study (AACES)

摘要: Ovarian cancer (OVCA) is the leading cause of death from gynecological cancer, with poorer survival for African American (AA) women compared to whites. However, little known about risk factors OVCA in AA. To study epidemiology this population, we started a collaborative effort 10 sites US. Here describe and highlight challenges conducting lethal disease minority population. The Cancer Epidemiology Study (AACES) an ongoing, population-based case–control AA geographic locations, aiming recruit 850 invasive epithelial controls age- geographically-matched cases. Rapid case ascertainment random-digit-dialing systems are place ascertain cases controls, respectively. A telephone survey focuses on as well particular relevance AAs. Food-frequency questionnaires, follow-up surveys, biospecimens medical records also obtained. Current accrual 403 639 exceeds that any existing date. We observed high proportion (15%) deceased non-responders among part explained by advanced stage at diagnosis. logistic regression model did not support socio-economic status was factor Most associations were expected direction magnitude. High BMI associated ovarian risk, multivariable adjusted ORs 95% CIs 1.50 (0.99-2.27) obese 1.27 (0.85- 1.91) morbidly normal/underweight women. AACES targets rare tumor AAs addresses issues most relevant importance accentuated ascertained deceased. Our analyses indicated obesity, highly prevalent population (>60% cases), increased risk. While these findings need be replicated, they suggest potential effective intervention Upon completion enrollment, will largest epidemiologic