Elg1, a central player in genome stability.
作者： Inbal Gazy , Batia Liefshitz , Oren Parnas , Martin Kupiec
DOI: 10.1016/J.MRREV.2014.11.007
关键词:
摘要: ELG1 is a conserved gene uncovered in number of genetic screens yeast aimed at identifying factors important the maintenance genome stability. Elg1's activity prevents gross chromosomal rearrangements, maintains proper telomere length regulation, helps repairing DNA damage created by genotoxins and participates sister chromatid cohesion. Elg1 evolutionarily conserved, its mammalian ortholog (also known as ATAD5) embryonic lethal when lost mice, acts tumor suppressor mice humans, exhibits physical interactions with components human Fanconi Anemia pathway may be responsible for some phenotypes associated neurofibromatosis. In this review, we summarize information available on Elg1-related activities mammals, present models to explain how different observed absence are related.
elsevier.com
sci-hub.se 参考文章(153)
Ronald T. Hay, SUMO: a history of modification Molecular Cell. ,vol. 18, pp. 1- 12 ,(2005) , 10.1016/J.MOLCEL.2005.03.012
Clark Chen, Richard D. Kolodner, Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nature Genetics. ,vol. 23, pp. 81- 85 ,(1999) , 10.1038/12687
Yang Xie, Oliver Kerscher, Mary B. Kroetz, Heather F. McConchie, Patrick Sung, Mark Hochstrasser, The Yeast Hex3·Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation Journal of Biological Chemistry. ,vol. 282, pp. 34176- 34184 ,(2007) , 10.1074/JBC.M706025200
Jerzy Majka, Peter M.J Burgers, The PCNA–RFC Families of DNA Clamps and Clamp Loaders Progress in Nucleic Acid Research and Molecular Biology. ,vol. 78, pp. 227- 260 ,(2004) , 10.1016/S0079-6603(04)78006-X
Göran O. Bylund, Jerzy Majka, Peter M.J. Burgers, Overproduction and Purification of RFC‐Related Clamp Loaders and PCNA‐Related Clamps from Saccharomyces cerevisiae DNA Repair, Part B. ,vol. 409, pp. 1- 11 ,(2006) , 10.1016/S0076-6879(05)09001-4
Agnieszka Halas, Agnieszka Podlaska, Joanna Derkacz, Justyna McIntyre, Adrianna Skoneczna, Ewa Sledziewska-Gojska, The roles of PCNA SUMOylation, Mms2-Ubc13 and Rad5 in translesion DNA synthesis in Saccharomyces cerevisiae. Molecular Microbiology. ,vol. 80, pp. 786- 797 ,(2011) , 10.1111/J.1365-2958.2011.07610.X
J Miles, T Formosa, Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase alpha, acts in DNA metabolism in vivo. Molecular and Cellular Biology. ,vol. 12, pp. 5724- 5735 ,(1992) , 10.1128/MCB.12.12.5724
N Kouprina, E Kroll, V Bannikov, V Bliskovsky, R Gizatullin, A Kirillov, B Shestopalov, V Zakharyev, P Hieter, F Spencer, CTF4 (CHL15) mutants exhibit defective DNA metabolism in the yeast Saccharomyces cerevisiae. Molecular and Cellular Biology. ,vol. 12, pp. 5736- 5747 ,(1992) , 10.1128/MCB.12.12.5736
Boris Pfander, John F X Diffley, Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. The EMBO Journal. ,vol. 30, pp. 4897- 4907 ,(2011) , 10.1038/EMBOJ.2011.345
Kyungjae Myung, Clark Chen, Richard D. Kolodner, Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae Nature. ,vol. 411, pp. 1073- 1076 ,(2001) , 10.1038/35082608