Tumor-suppressive Pathways in Pancreatic Carcinoma

摘要: During tumorigenesis, positive selection is exerted upon those tumor cells that alter rate-limiting regulatory pathways. A corollary of this principle mutation one gene abrogates the need for alteration another in same pathway and also coexistence a single mutations different genes implies their involvement distinct tumor-suppressive We studied 42 pancreatic adenocarcinomas genetic alterations K-ras oncogene p16, p53, DPC4 suppressor genes. All them had mutated. Thirty-eight % tumors four altered genes, 38% three 15% two 8% gene. Interestingly, we noted high concordance p16 inactivations (P = 0.007), suggesting inactivation increases selective advantage subsequent DPC4. No statistically significant association was identified between these cancer pathological or clinical parameters. This type multigenic analysis human may serve to substantiate experimental models thus increase our understanding truly physiologically relevant pathways are abrogated during tumorigenesis.