Cytohistologic correlations of 24 malignant peripheral nerve sheath tumor (MPNST) in 17 patients: The Institut Curie experience

摘要: Cytomorphological patterns of malignant peripheral nerve sheath tumor (MPNST) are insufficiently documented in the literature. Cytological and histological specimens 24 tumors 17 patients were correlated. The review original cytology reports showed that four (16.6%) correctly diagnosed, eight (33.3%) diagnosed as sarcoma not otherwise specified, (16.7%) fibrosarcoma, three (12.5%) synovial sarcoma, leiomyosarcoma, one (4.2%) case each fibrous histiocytoma rhabdomyosarcoma. At histologically reclassified well-differentiated MPNST 11 (45.9%) cases, anaplastic epithelioid Triton each. Cytologically, composed polymorphous oval to round cells, small spindle-shaped cells with wavy comma-like naked nuclei, a fibrillary, delicate stroma. Anaplastic MPNST, moreover, giant cells. was rhabdomyoblastic eccentric nuclei round, epithelial-like cytological diagnosis may be difficult, especially tumors. correlation between features clinical information—origin from trunk, preexisting neurofibroma, known history neurofibromatosis 1—could indicative an diagnosis. Diagn. Cytopathol. 2002;27:103–108. © 2002 Wiley-Liss, Inc.