The effects of plasma and brain magnesium concentrations on lidocaine-induced seizures in the rat.

摘要: Lidocaine and MgSO4 are often coadministered to patients with pregnancy-induced hypertension. This study examined whether alters the lidocaine-seizure threshold in rat and, if so, systemic administration is as effective intracerebroventricular infusion. In Experiment 1, rats were administered 50% or 0.9% NaCl intravenously (IV) (20 microL/h) for 5 days. 2, NaCl, 0.8% MgSO4, 2.0% (10 via infusion 24 h. All then underwent continuous IV lidocaine until onset of electroencephalographic seizures. plasma [Mg2+] was greater group (5.1 +/- 1.5 mg/dL vs 1.8 0.3 mg/dL) but neither dose required induce seizures (MgSO4 = 19 2 mg/kg; saline 23 mg/kg) nor brain 794 17 micrograms/g; 788 33 micrograms/g) changed. increased both (2% 923 79 35 seizure 39 7 26 3 mg/kg). Although produces an anticonvulsant effect, chronic hypermagnesemia does not alter whole therefore offers no protection from lidocaine-induced this model.