Cellular cancer vaccines: an update on the development of vaccines generated from cell surface antigens.

摘要: A recent advance in anti-cancer therapies has been the use of cancer cells to develop vaccines. However, immunization with cell-based vaccines not resulted significant long-term therapeutic benefits. possible reason for this is that while provide surface antigens are targets a desired immune response, they also contain high abundance housekeeping proteins, carbohydrates, nucleic acids, lipids, and other intracellular contents ubiquitous all mammalian cells. These molecules intended therapy approach, thus, response generated sufficient eliminate present. In review, discussion cell presented relation goals improving antigen composition Strategies enrich cancer-specific discussed.