A CMOS Neural Interface for a Multichannel Vestibular Prosthesis

摘要: We present a high-voltage CMOS neural-interface chip for multichannel vestibular prosthesis (MVP) that measures head motion and modulates nerve activity to restore vision- posture-stabilizing reflexes. This application specific integrated circuit neural interface (ASIC-NI) was designed work with commercially available microcontroller, which controls the ASIC-NI via fast parallel deliver biphasic stimulation pulses 9-bit programmable current amplitude 16 channels. The fabricated in ONSemi C5 0.5 micron, process can accommodate compliance voltages up 12 V, stimulating branches using $1.45\pm 0.06~{\rm mA}$ durations as short 10 $\mu {\rm s}/{\rm phase}$ . includes dedicated digital-to-analog converter each channel, enabling it perform complex multipolar stimulation. replaces discrete components cover nearly half of 2nd generation MVP (MVP2) printed board, reducing system size by 48% power consumption 17%. Physiological tests ASIC-based (MVP2A) rhesus monkey produced reflexive eye movement responses prosthetic similar those observed when MVP2. Sinusoidal modulation stimulus pulse rate from 68–130 per second at frequencies 0.1 5 Hz elicited appropriately-directed slow phase velocities ranging 1.9–16.7 $^{\circ}/{\rm s}$ MVP2 2.0–14.2 MVP2A. evoked MVP2A showed no significant difference ( ${\rm t}$ -test, p}=0.34$ ), suggesting achieves performance least good larger