Gastrointestinal Infection Increases Odds of Inflammatory Bowel Disease in a Nationwide Case-Control Study.
作者： Jordan E. Axelrad , Ola Olén , Johan Askling , Benjamin Lebwohl , Hamed Khalili
DOI: 10.1016/J.CGH.2018.09.034
关键词:
摘要: Background & Aims Gastrointestinal infections have been associated with later development of inflammatory bowel diseases (IBD). However, studies produced conflicting results. We performed a nationwide case–control study in Sweden to determine whether gastroenteritis is the Crohn’s disease (CD) or ulcerative colitis (UC). Methods Using Swedish National Patient Register, we identified 44,214 patients IBD (26,450 UC; 13,387 CD; and 4377 IBD-unclassified) from 2002 2014 matched them 436,507 individuals general population (control subjects). then control subjects reported episodes (from 1964 2014) type pathogen associated. collected medical demographic data used logistic regression estimate odds ratios (ORs) for enteric infection. Results Of IBD, 3105 (7.0%) (1672 UC, 1050 CD, 383 had record previous compared 17,685 (4.1%). cases higher an antecedent episode gastrointestinal infection (aOR, 1.64; 1.57–1.71), bacterial 2.02; 1.82–2.24), parasitic 1.55; 1.03–2.33), viral 1.34–1.79). Patients UC Salmonella, Escherichia coli, Campylobacter, Clostridium difficile subjects. CD Yersinia enterocolitica, C difficile, amoeba, norovirus Increasing numbers were increased remained more than 10 years 1.26; 1.19–1.33). Conclusions In analysis found increase IBD. Although cannot formally exclude misclassification bias, might induce microbial dysbiosis that contributes susceptible individuals.
cghjournal.org参考文章(27)
Charisse Petersen, June L. Round, Defining dysbiosis and its influence on host immunity and disease. Cellular Microbiology. ,vol. 16, pp. 1024- 1033 ,(2014) , 10.1111/CMI.12308
Marla Dubinsky, Jonathan Braun, Diagnostic and Prognostic Microbial Biomarkers in Inflammatory Bowel Diseases. Gastroenterology. ,vol. 149, pp. 1265- 1274 ,(2015) , 10.1053/J.GASTRO.2015.08.006
Luis Alberto García Rodríguez, Ana Ruigómez, Julián Panés, Acute Gastroenteritis Is Followed by an Increased Risk of Inflammatory Bowel Disease Gastroenterology. ,vol. 130, pp. 1588- 1594 ,(2006) , 10.1053/J.GASTRO.2006.02.004
T. W. Hand, L. M. Dos Santos, N. Bouladoux, M. J. Molloy, A. J. Pagan, M. Pepper, C. L. Maynard, C. O. Elson, Y. Belkaid, Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses Science. ,vol. 337, pp. 1553- 1556 ,(2012) , 10.1126/SCIENCE.1220961
Jessica Keithlin, Jan Sargeant, M Kate Thomas, Aamir Fazil, Systematic review and meta-analysis of the proportion of Campylobacter cases that develop chronic sequelae BMC Public Health. ,vol. 14, pp. 1203- 1203 ,(2014) , 10.1186/1471-2458-14-1203
Vanessa M. Hubbard, Ken Cadwell, Viruses, Autophagy Genes, and Crohn's Disease Viruses. ,vol. 3, pp. 1281- 1311 ,(2011) , 10.3390/V3071281
Janet Chow, Haiqing Tang, Sarkis K Mazmanian, Pathobionts of the gastrointestinal microbiota and inflammatory disease Current Opinion in Immunology. ,vol. 23, pp. 473- 480 ,(2011) , 10.1016/J.COI.2011.07.010
Chad K. Porter, David R. Tribble, Pablo A. Aliaga, Heather A. Halvorson, Mark S. Riddle, Infectious gastroenteritis and risk of developing inflammatory bowel disease. Gastroenterology. ,vol. 135, pp. 781- 786 ,(2008) , 10.1053/J.GASTRO.2008.05.081
T. Jess, J. Simonsen, N. M. Nielsen, K. T. Jorgensen, P. Bager, S. Ethelberg, M. Frisch, Enteric Salmonella or Campylobacter infections and the risk of inflammatory bowel disease Gut. ,vol. 60, pp. 318- 324 ,(2011) , 10.1136/GUT.2010.223396
Luke Jostins, Stephan Ripke, Rinse K Weersma, Richard H Duerr, Dermot P McGovern, Ken Y Hui, James C Lee, L Philip Schumm, Yashoda Sharma, Carl A Anderson, Jonah Essers, Mitja Mitrovic, Kaida Ning, Isabelle Cleynen, Emilie Theatre, Sarah L Spain, Soumya Raychaudhuri, Philippe Goyette, Zhi Wei, Clara Abraham, Jean-Paul Achkar, Tariq Ahmad, Leila Amininejad, Ashwin N Ananthakrishnan, Vibeke Andersen, Jane M Andrews, Leonard Baidoo, Tobias Balschun, Peter A Bampton, Alain Bitton, Gabrielle Boucher, Stephan Brand, Carsten Büning, Ariella Cohain, Sven Cichon, Mauro D’amato, Dirk De Jong, Kathy L Devaney, Marla Dubinsky, Cathryn Edwards, David Ellinghaus, Lynnette R Ferguson, Denis Franchimont, Karin Fransen, Richard Gearry, Michel Georges, Christian Gieger, Jürgen Glas, Talin Haritunians, Ailsa Hart, Chris Hawkey, Matija Hedl, Xinli Hu, Tom H Karlsen, Limas Kupcinskas, Subra Kugathasan, Anna Latiano, Debby Laukens, Ian C Lawrance, Charlie W Lees, Edouard Louis, Gillian Mahy, John Mansfield, Angharad R Morgan, Craig Mowat, William Newman, Orazio Palmieri, Cyriel Y Ponsioen, Uros Potocnik, Natalie J Prescott, Miguel Regueiro, Jerome I Rotter, Richard K Russell, Jeremy D Sanderson, Miquel Sans, Jack Satsangi, Stefan Schreiber, Lisa A Simms, Jurgita Sventoraityte, Stephan R Targan, Kent D Taylor, Mark Tremelling, Hein W Verspaget, Martine De Vos, Cisca Wijmenga, David C Wilson, Juliane Winkelmann, Ramnik J Xavier, Sebastian Zeissig, Bin Zhang, Clarence K Zhang, Hongyu Zhao, International IBD Genetics Consortium (IIBDGC), Mark S Silverberg, Vito Annese, Hakon Hakonarson, Steven R Brant, Graham Radford-Smith, Christopher G Mathew, John D Rioux, Eric E Schadt, Mark J Daly, Andre Franke, Miles Parkes, Severine Vermeire, Jeffrey C Barrett, Judy H Cho, None, Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease Nature. ,vol. 491, pp. 119- 124 ,(2012) , 10.1038/NATURE11582