Gross composition and plasma and extracellular water volumes of tissues of a reference mouse.

摘要: The laboratory mouse is a primary animal model for experimental radiation biology and pharmacology. usefulness of the those purposes enhanced if detailed data are available to define Reference Mouse [weight composition soft tissues bones their in-life content plasma extracellular water (ECW)]. Only fragmentary wet weights volumes mice; there no reports total volume or distribution ECW in tissues. To remedy defects, weight all major organs were measured, measurements made estimates obtained young adult (12 13 wk old) female Swiss-Webster mouse. 125I-transferrin was used as tracer plasma, 22Na ECW. Tissue conducted using metabolic balance approach freezing technique that avoids blood loss during dissection. Results compare favorably with published mature mice both genders other strains. Total (48.9 +/- 4.4 microL g-1) Na-space (232 15 g-1), specific vascular tissues, exceed rat Applications presented: (1) interpretation plutonium uptake kinetics mouse; (2) estimation masses mineralized bone tissue (1.92 g), marrow (1.2 endosteal (BS) cells (0.2 g)