Reliability of Rodent Models
作者： Dileep Kumar Rohra , Yureeda Qazi
DOI: 10.1007/978-1-59745-285-4_24
关键词:
摘要: Despite the discrepancies observed between data generated from humans and animals, it is common practice to extrapolate animal models humans. This chapter discusses usefulness of in research development, but also stresses need exercise caution interpreting results. Complete reliance on results experiments can be dangerously misleading, resulting damage human health as well loss valuable time resources. Furthermore, we will elaborate validity reliability rodent models, role confounding factors using precautionary advice when extrapolating obtained a larger, heterogeneous population.
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Dileep Kumar Rohra, Ali Jawaid, Ali Hyder Zaidi, None, Reliability of rodent animal models in biomedical research. Jcpsp-journal of The College of Physicians and Surgeons Pakistan. ,vol. 15, pp. 809- ,(2005)
J. M. Behnke, G. A. Schad, K. S. Warren, Laboratory animal models. Hookworm disease - current status and new directions.. pp. 105- 128 ,(1990)
László Patthy, Modular assembly of genes and the evolution of new functions. Genetica. ,vol. 118, pp. 217- 231 ,(2003) , 10.1023/A:1024182432483
C T Esmon, The roles of protein C and thrombomodulin in the regulation of blood coagulation. Journal of Biological Chemistry. ,vol. 264, pp. 4743- 4746 ,(1989) , 10.1016/S0021-9258(18)83649-3
Vincent T.K. Chow, Pandjassarame Kangueane, Meena Kishore Sakharkar, Distributions of exons and introns in the human genome. in Silico Biology. ,vol. 4, pp. 387- 393 ,(2004)
Barbara Lubec, Michael Hermon, Harald Hoeger, Gert Lubec, Aromatic hydroxylation in animal models of diabetes mellitus The FASEB Journal. ,vol. 12, pp. 1581- 1587 ,(1998) , 10.1096/FASEBJ.12.14.1581
Paul Willner, Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation Psychopharmacology. ,vol. 134, pp. 319- 329 ,(1997) , 10.1007/S002130050456
Nancy C. Tkacs, Hilaire J. Thompson, From bedside to bench and back again: research issues in animal models of human disease. Biological Research For Nursing. ,vol. 8, pp. 78- 88 ,(2006) , 10.1177/1099800406289717
Rakesh K. Kumar, Paul S. Foster, Modeling allergic asthma in mice: pitfalls and opportunities. American Journal of Respiratory Cell and Molecular Biology. ,vol. 27, pp. 267- 272 ,(2002) , 10.1165/RCMB.F248
Amy J. Davidoff, Judith K. Gwathmey, Pathophysiology of cardiomyopathies Current Opinion in Cardiology. ,vol. 9, pp. 357- ,(1994) , 10.1097/00001573-199405000-00015