Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation.

摘要: The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing gut-secretin-BAT-brain axis in mammals with physiological role control satiation. Mechanistically, rise circulating activates by stimulating lipolysis upon binding to receptors adipocytes, is sensed brain promotes Chronic infusion modified human transiently elevates energy expenditure diet-induced obese mice. Clinical trials subjects showed that after single-meal ingestion correlated postprandial levels infusions increased glucose uptake BAT. Collectively, our findings highlight largely unappreciated function satiation qualify an even more attractive target for treating obesity.