Apoptosis in the Resolution of Systemic Inflammation

摘要: Admission to a contemporary ICU is precipitated by heterogeneous group of disease processes, yet the final common pathway death strikingly similar [1]. Fully 80% all deaths occur in association with multiple organ dysfunction syndrome (MODS) [2], poorly understood process characterized development progressive physiologic systems initially unaffected primary process. Activation host inflammatory response infection, injury, or ischemia, invariably proceeds MODS [3]. The proximate causes injury are not bacterial products, but same endogenous host-derived mediators inflammation that responsible for containing an infectious challenge and initiating tissue repair. can be conceptualized as consequence overly activated inappropriately prolonged systemic response, therefore understanding mechanisms underlying resolution important clinical strategies prevent syndrome.