Nanomechanical Cantilever Array Sensors

摘要: In recent years, mechanics has experienced a revival, as microfabrication technologies and nanotechnology are applied to produce tiny structures. The development of ultraprecise position sensing started three decades ago with novel imaging technique called atomic force microscopy, which provides ultrahigh topography resolution on the scale by raster-scanning surface microfabricated cantilever beam that tip at its free end. high sensitivity can not only be used for imaging, but also allows measurement forces during molecule adsorption processes surface, thus enabling cantilevers act chemical sensors. Because their small size, allow fast reliable detection concentrations molecules in air solution. addition artificial nose label-free biosensing applications, they have been employed measure physical properties amounts materials miniaturized versions conventional standard techniques such calorimetry, thermogravimetry, weighing, photothermal spectroscopy monitoring reactions. past few cantilever-sensor concept extended medical applications entered clinics pilot studies patients. size scalability array sensors might turn out advantageous diagnostic screening disease monitoring, well genomics or proteomics. Using microcantilever arrays simultaneous several analytes solves inherent problem thermal drifts often present when using single sensors, some sensor detection, others passivated reference do show affinity detected.