A nanostructured conductive bio-composite of silk fibroin–single walled carbon nanotubes

作者: Chiara Dionigi , Tamara Posati , Valentina Benfenati , Anna Sagnella , Assunta Pistone

DOI: 10.1039/C3TB21172J

关键词:

摘要: Silk fibroin (SF), a protein core fibre from the silkworm Bombyx mori, has huge potential to become sustainable, biocompatible, and biodegradable material platform that can pave way towards replacement of plastic in fabrication bio-derived materials for variety technological biomedical applications. SF remarkable mechanical flexibility, controllable biodegradability, biocompatibility is capable drug/doping inclusion, stabilization release. However, dielectric properties limit its as direct bioelectronic interface devices intended control bioelectrical activity cell regenerative purposes. In this work, novel wet templating method proposed generate nanostructured, conductive Fibroin (SF) composite films. We combine unusual SF, such properties, convenience with electrical conductivity stiffness Single Walled Carbon Nanotubes (SWCNTs). The presented SF–SWCNT displays periodic architecture where SWCNTs are regularly homogeneously distributed matrix. morphological chemo-physical nanocomposite analysed defined by SEM, Raman Spectroscopy, ATR-IR, UFM contact angle analyses. Notably, film conductive, showing additional functionality compared bare film. Finally, biocompatible enables growth primary rat Dorsal Root Ganglion (DRG) neurons. Collectively our results demonstrate robust be fabricated using method, paving development silk-based electronic use

参考文章(45)
Seong‐Jun Yoon, Jong H Kim, Kil Suk Kim, Jong Won Chung, Benoît Heinrich, Fabrice Mathevet, Pyosang Kim, Bertrand Donnio, André‐Jean Attias, Dongho Kim, Soo Young Park, None, Liquid Crystals: Mesomorphic Organization and Thermochromic Luminescence of Dicyanodistyrylbenzene‐Based Phasmidic Molecular Disks: Uniaxially Aligned Hexagonal Columnar Liquid Crystals at Room Temperature with Enhanced Fluorescence Emission and Semiconductivity (Adv. Funct. Mater. 1/2012) Advanced Functional Materials. ,vol. 22, pp. 1- 1 ,(2012) , 10.1002/ADFM.201290004
C. Selhuber-Unkel, T. Erdmann, M. López-García, H. Kessler, U.S. Schwarz, J.P. Spatz, Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors Biophysical Journal. ,vol. 98, pp. 543- 551 ,(2010) , 10.1016/J.BPJ.2009.11.001
Antony S. Dimitrov, Kuniaki Nagayama, Steady-state unidirectional convective assembling of fine particles into two-dimensional arrays Chemical Physics Letters. ,vol. 243, pp. 462- 468 ,(1995) , 10.1016/0009-2614(95)00837-T
Dirk Lehnert, Bernhard Wehrle-Haller, Christian David, Ulrich Weiland, Christoph Ballestrem, Beat A Imhof, Martin Bastmeyer, Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion Journal of Cell Science. ,vol. 117, pp. 41- 52 ,(2004) , 10.1242/JCS.00836
Dion Khodagholy, Thomas Doublet, Pascale Quilichini, Moshe Gurfinkel, Pierre Leleux, Antoine Ghestem, Esma Ismailova, Thierry Hervé, Sébastien Sanaur, Christophe Bernard, George G. Malliaras, In vivo recordings of brain activity using organic transistors Nature Communications. ,vol. 4, pp. 1575- 1575 ,(2013) , 10.1038/NCOMMS2573
Hu Tao, Jason J. Amsden, Andrew C. Strikwerda, Kebin Fan, David L. Kaplan, Xin Zhang, Richard D. Averitt, Fiorenzo G. Omenetto, Metamaterial Silk Composites at Terahertz Frequencies Advanced Materials. ,vol. 22, pp. 3527- 3531 ,(2010) , 10.1002/ADMA.201000412
Gabriel A. Silva, Neuroscience nanotechnology: progress, opportunities and challenges Nature Reviews Neuroscience. ,vol. 7, pp. 65- 74 ,(2006) , 10.1038/NRN1827
Elisa Migliorini, Gianluca Grenci, Jelena Ban, Alessandro Pozzato, Massimo Tormen, Marco Lazzarino, Vincent Torre, Maria Elisabetta Ruaro, Acceleration of neuronal precursors differentiation induced by substrate nanotopography Biotechnology and Bioengineering. ,vol. 108, pp. 2736- 2746 ,(2011) , 10.1002/BIT.23232
Salvador Aznar-Cervantes, Maria I. Roca, Jose G. Martinez, Luis Meseguer-Olmo, Jose L. Cenis, Jose M. Moraleda, Toribio F. Otero, Fabrication of conductive electrospun silk fibroin scaffolds by coating with polypyrrole for biomedical applications. Bioelectrochemistry. ,vol. 85, pp. 36- 43 ,(2012) , 10.1016/J.BIOELECHEM.2011.11.008