Normal Polymorphism in the Incomplete Trinucleotide Repeat of the Arginine-Rich Protein Gene

摘要: The arginine-rich protein (ARP) gene was recently cloned and localized to human chromosome band 3p21. Recent reports have suggested that ARP is mutated in a high percentage of different tumors. We amplified sequenced the multiple arginine coding area primary head neck, non-small cell lung, renal cancers. found frequency genetic changes this region, including single base pair substitution deletions repeats However, these were always present matched normal controls. Thus, variations trinucleotide repeat region represent polymorphisms rather than tumor-specific mutations.